Epi-LASEK, or Laser Assisted Subepithelial Keratectomy, is a modification of the LASIK and PRK procedures. A flap of tissue is created in the outer layer of the cornea with a trephine. The eye is bathed in a special solution, then the flap is lifted so the central cornea may be treated with an excimer laser.

More of the cornea is exposed for treatment than with LASIK, making Epi-LASEK a better choice for patients who require greater vision correction. After treatment the flap is replaced and allowed to heal. A contact lens may be worn for a few days until recovery is complete. Advantages of Epi-LASEK over PRK are diminished pain, shorter recovery time and a lower risk of infection.